The studies described in this work were designed to evaluate a new sublingual tablet system using low doses of piroxicam. In this system, water-soluble carrier particles are covered with piroxicam and a bioadhesive material during dry mixing. The formulation was evaluated and compared to the influence of accelerated-aging conditions on the drug content and in vitro dissolution stability of piroxicam fast disintegrating mucoadhesive tablet. Dissolution efficiency (DE) was calculated from dissolution profiles that were performed according to the United State Pharmacopoeia monograph. This determination was performed at time zero, one and three months of storage; (40�°C/75% RH). Each formulation was compared with the reference at the specified times, in terms of DE and similarity factor f2. The in vitro drug release was studied in pH 7.2 Phosphate buffer using Franz diffusion cell. The model independent methods were used to estimate the kinetics of drug release. The criteria for selecting the most appropriate model were based on the goodness-of-fit test. Furthermore, experimentally, we assessed the in vitro transfer of the prepared piroxicam non aqueous emulsion for steady state flux and permeability coefficient through an artificial cellulose acetate membrane.
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